{"id":10584,"date":"2019-10-09T09:00:00","date_gmt":"2019-10-09T09:00:00","guid":{"rendered":"http:\/\/reasons.org\/is-the-optimal-set-of-protein-amino-acids-purposed-by-a-mind\/"},"modified":"2019-10-09T09:00:00","modified_gmt":"2019-10-09T09:00:00","slug":"is-the-optimal-set-of-protein-amino-acids-purposed-by-a-mind","status":"publish","type":"post","link":"https:\/\/reasons.org\/creation\/life\/is-the-optimal-set-of-protein-amino-acids-purposed-by-a-mind","title":{"rendered":"Is the Optimal Set of Protein Amino Acids Purposed by a Mind?"},"content":{"rendered":"<section class=\"post-norm\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-sm-8 col-sm-offset-2\">\n<!-- CONTENT BEGINS --><\/p>\n<p>As a graduate student and a postdoc, I spent countless hours in the lab doing research. Part of my work involved performing <a href=\"https:\/\/en.wikipedia.org\/wiki\/Assay\">biochemical assays<\/a>\u2014laboratory procedures designed to measure the activities of biomolecules and biochemical systems.<\/p>\n<p>To get our assays to work properly, we had to carefully design and optimize each test before executing it with exacting precision in the laboratory. Optimizing these assays was no easy feat. It could take weeks of painstaking effort to get the protocols just right.<\/p>\n<p>My experiences working in the lab taught me some important lessons that I carry with me today as a Christian apologist. One of these lessons has to do with optimization. Optimized systems don\u2019t just happen, whether they are laboratory procedures, manufacturing operations, or well-designed objects or devices. Instead, optimization results from the insights and efforts of intelligent agents, and therefore serves as a sure indicator of intelligent design.<\/p>\n<p>As it turns out, nearly every biochemical system appears to be highly optimized. For me, this fact indicates that life stems from a Mind. And as life scientists continue to characterize biochemical systems, they keep discovering more and more examples of biochemical optimization, as recent work by a large team of collaborators working at the Earth-Life Science Institute (ELSI) in Tokyo, Japan, illustrates.<sup>1 <\/sup><\/p>\n<p>These researchers uncovered more evidence that the twenty amino acids encoded by the genetic code possess the optimal set of physicochemical properties. If not for these properties, it would not be possible for the cell to build proteins that could support the wide range of activities required to sustain living systems. This insight gives us important perspective into the structure-function relationships of proteins. It also has theological significance, adding to the biochemical case for a Creator.<\/p>\n<p>Before describing the ELSI team\u2019s work and its theological implications, a little background might be helpful for some readers. For those who are familiar with basic biochemistry, just skip ahead to <strong>Why These Twenty Amino Acids?<\/strong><\/p>\n<p><strong>Background: Protein Structure<\/strong><\/p>\n<p>Proteins are large, complex molecules that play a key role in virtually all of the cell\u2019s operations. Biochemists have long known that the three-dimensional structure of a protein dictates its function. Because proteins are such large, complex molecules, biochemists categorize protein structure into four different levels: primary, secondary, tertiary, and quaternary structures.<\/p>\n<p><img decoding=\"async\" class=\"img-responsive center-block\" src=\"65ca7847-1f86-66f3-b463-ff00002b9606\" data-displaymode=\"Original\" alt=\"blog__inline-is-the-optimal-set-of-protein-amino-acids-1\" title=\"blog__inline-is-the-optimal-set-of-protein-amino-acids-1\" \/><\/p>\n<p style=\"text-align: left;\"><em><strong>Figure 1: The Four Levels of Protein Structure.<\/strong> Image credit: <a href=\"https:\/\/www.shutterstock.com\/image-vector\/structure-proteins-1266467857?src=T8ep-QMOTYCpGxApK4k1mw-1-0\">Shutterstock<\/a><\/em><\/p>\n<ul>\n<li>A protein\u2019s primary structure is the linear sequence of amino acids that make up each of its polypeptide chains.<\/li>\n<li>The secondary structure refers to short-range three-dimensional arrangements of the polypeptide chain\u2019s backbone arising from the interactions between chemical groups that make up its backbone. Three of the most common secondary structures are the random coil, alpha (\u03b1) helix, and beta (\u03b2) pleated sheet.<\/li>\n<li>Tertiary structure describes the overall shape of the entire polypeptide chain and the location of each of its atoms in three-dimensional space. The structure and spatial orientation of the chemical groups that extend from the protein backbone are also part of the tertiary structure.<\/li>\n<li>Quaternary structure arises when several individual polypeptide chains interact to form a functional protein complex.<\/li>\n<\/ul>\n<p style=\"text-align: left;\"><strong>Background: Amino Acids<\/strong><\/p>\n<p>The building blocks of proteins are amino acids. These compounds are characterized by having both an amino group and a carboxylic acid bound to a central carbon atom. Also bound to this carbon are a hydrogen atom and a substituent that biochemists call an R group.<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"img-responsive center-block\" src=\"75ca7847-1f86-66f3-b463-ff00002b9606\" data-displaymode=\"Original\" alt=\"blog__inline-is-the-optimal-set-of-protein-amino-acids-2\" title=\"blog__inline-is-the-optimal-set-of-protein-amino-acids-2\" \/><\/p>\n<p style=\"text-align: left;\"><em><strong>Figure 2: The Structure of a Typical Amino Acid.<\/strong> Image credit: <a href=\"https:\/\/www.shutterstock.com\/image-vector\/general-formula-amino-acids-which-building-783423997?src=Yl6lnf2WK-nAtgXPTb5AdQ-1-11\">Shutterstock<\/a><\/em><\/p>\n<p>The R group determines the amino acid\u2019s identity. For example, if the R group is hydrogen, the amino acid is called glycine. If the R group is a methyl group, the amino acid is called alanine.<\/p>\n<p>Close to 150 amino acids are found in proteins. But only 19 amino acids (plus 1 imino acid, called proline) are specified by the genetic code. Biochemists refer to these 20 as the canonical set.<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"img-responsive center-block\" src=\"85ca7847-1f86-66f3-b463-ff00002b9606\" data-displaymode=\"Original\" alt=\"blog__inline-is-the-optimal-set-of-protein-amino-acids-3\" title=\"blog__inline-is-the-optimal-set-of-protein-amino-acids-3\" \/><\/p>\n<p style=\"text-align: left;\"><em><strong>Figure 3: The Protein-Forming Amino Acids.<\/strong> Image credit: <a href=\"https:\/\/www.shutterstock.com\/image-illustration\/educational-chart-all-common-amino-acids-386426320?src=JhiOIq4Kh-SADDiFJpZhsQ-1-9\">Shutterstock<\/a><\/em><\/p>\n<p>A protein\u2019s primary structure forms when amino acids react with each other to form a linear chain, with the amino group of one amino acid combining with the carboxylic acid of another to form an amide linkage. (Sometimes biochemists call the linkage a peptide bond.)<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"img-responsive center-block\" src=\"95ca7847-1f86-66f3-b463-ff00002b9606\" data-displaymode=\"Original\" alt=\"blog__inline-is-the-optimal-set-of-protein-amino-acids-4\" title=\"blog__inline-is-the-optimal-set-of-protein-amino-acids-4\" \/><\/p>\n<p style=\"text-align: left;\"><em><strong>Figure 4: The Chemical Linkage between Amino Acids.<\/strong> Image credit: <a href=\"https:\/\/www.shutterstock.com\/image-vector\/formation-peptide-band-1278184660?src=DGTzzz5-0YFC9OA0K4OEqA-1-0\">Shutterstock<\/a><\/em><\/p>\n<p>The repeating amide linkages along the amino acid chain form the protein\u2019s backbone. The amino acids\u2019 R groups extend from the backbone, creating a distinct physicochemical profile along the protein chain for each unique amino acid sequence. To first approximation, this unique physicochemical profile dictates the protein\u2019s higher-order structures and, hence, the protein\u2019s function.<\/p>\n<p><strong>Why These Twenty Amino Acids?<\/strong><\/p>\n<p>Research has revealed that the set of amino acids used to build proteins is universal. In other words, the proteins found in every organism on Earth are made up of the same canonical set.<\/p>\n<p>Biochemists have long wondered: Why these 20 amino acids?<\/p>\n<p>In the early 1980s biochemists discovered that an exquisite molecular rationale undergirds the amino acid set used to make proteins.<sup>2<\/sup> Every aspect of amino acid structure has to be precisely the way it is for life to be possible. On top of that, biochemists concluded that the set of 20 amino acids possesses the \u201cjust-right\u201d physical and chemical properties that evenly and uniformly vary across a broad range of size, charge, and hydrophobicity (water resistance). In fact, it appears as if the amino acids selected for proteins seem to form a uniquely optimal set of 20 amino acids compared to random sets of amino acids.<sup>3<\/sup><\/p>\n<p>With these previous studies as a backdrop, the ELSI investigators wanted to develop a better understanding of the optimal nature of the universal set of amino acids used to build proteins. They also wanted to gain insight into the origin of the canonical set.<\/p>\n<p>To do this they used a library of 1,913 amino acids (including the 20 amino acids that make up the canonical set) to construct random sets of amino acids. The researchers varied the set sizes from 3 to 20 amino acids and evaluated the performance of the random sets in terms of their capacity to support: (1) the folding of protein chains into three-dimensional structures; (2) protein catalytic activity; and (3) protein solubility.<\/p>\n<p>They discovered that if a random set of amino acids included even a single amino acid from the canonical set, it dramatically out-performed random sets of the same size without any of the canonical amino acids. Based on these results, the researchers concluded that each of the 20 amino acids used to build proteins stands out, possessing highly unusual properties that make them ideally suited for their biochemical role, confirming the results of previous studies.<\/p>\n<p><strong>An Evolutionary Origin for the Canonical Set?<\/strong><\/p>\n<p>The ELSI researchers believe that\u2014from an evolutionary standpoint\u2014these results also shed light as to how the canonical set of amino acids emerged. Because of the unique adaptive properties of the canonical amino acids, the researchers speculate that \u201ceach time a CAA [canonical amino acid] was discovered and embedded during evolution, it provided an adaptive value unusual among many alternatives, and each selective step may have helped bootstrap the developing set to include still more CAAs.\u201d<sup>4<\/sup><\/p>\n<p>In other words, the researchers offer the conjecture that whenever the evolutionary process stumbled upon one of the amino acids in the canonical set and incorporated it into nascent biochemical systems, the addition offered such a significant  evolutionary advantage that it became instantiated into the biochemistry of the emerging cellular systems. Presumably, as this selection process occurred repeatedly over time, members of the canonical set would be added, one by one, to the evolving amino acid set, eventually culminating in the full canonical set.<\/p>\n<p>Scientists find further support for this scenario in the following observation: some of the canonical amino acids seemingly play a more important role in optimizing smaller sets of amino acids, some play a more important role in optimizing intermediate size sets of amino acids, and others play a more prominent role in optimizing larger sets. They argue that this difference may reflect the sequence by which amino acids were added to the evolving set of amino acids as life emerged.<\/p>\n<p>On the surface, this evolutionary explanation is not unreasonable. But more careful consideration of the idea raises concerns. For example, just because a canonical amino acid becomes incorporated into a set of amino acids and improves its adaptive value doesn\u2019t mean that the resulting set of amino acids could produce the range of proteins with the solubility, foldability, and catalytic range needed to support life processes. Intuitively, it seems to me as a biochemist, that there must be a threshold for the number of canonical amino acids in any set of amino acids for it to have the range of physicochemical properties needed to build all the proteins needed to support minimal life.<\/p>\n<p>I also question this evolutionary scenario because some of the amino acids that optimize smaller sets would not have been the ones present initially on the early Earth because they cannot be made by prebiotic reactions. Instead, many of the amino acids that optimize smaller sets can only be generated through biosynthetic routes that must have emerged much later in any evolutionary scenario for the origin of life.<sup>5<\/sup> This limitation also means that the only way for some of the canonical amino acids to become incorporated into the canonical set is that multi-step biosynthetic routes for those amino acids evolved first. But if the full canonical set isn\u2019t available, then it is questionable if the proteins needed to catalyze the biosynthesis of these amino acid would exist, resulting in a chicken-and-egg dilemma.<\/p>\n<p>In light of these concerns, is there a better explanation for the highly optimized canonical set of amino acids?<\/p>\n<p><strong>A Creator\u2019s Role?<\/strong><\/p>\n<p>Optimality of the universal set of protein amino acids finds explanation if life stems from a Creator\u2019s handiwork. As noted, optimization is an indicator of intelligent design, achieved through foresight and preplanning. Optimization requires inordinate attention to detail and careful craftsmanship. By analogy, the optimized biochemistry epitomized by the amino acid set that makes up proteins rationally points to the work of a Creator.<\/p>\n<p><strong>Is There a Biochemical Anthropic Principle?<\/strong><\/p>\n<p>This discovery also leads to another philosophical implication: It lends support to the existence of a biochemical anthropic principle.<\/p>\n<p>The ELSI researchers speculate that no matter the starting point in the evolutionary process, the pathways will all converge at the canonical set of amino acids because of the acids\u2019 unusual adaptive properties. In other words, the amino acids that make up the universal set of protein-coding amino acids are not the outworking of an historically contingent evolutionary process, but instead seem to be fundamentally prescribed by the laws of nature. To put it differently, it appears as if the canonical set of amino acids has been preordained in some way.<sup>6<\/sup> One of the study\u2019s authors, Rudrarup Bose, suggests that \u201cLife may not be just a set of accidental events. Rather, there may be some universal laws governing the evolution of life.\u201d<sup>7<\/sup><\/p>\n<p>Though I prefer to see the origin of life as a creation event, it is important to recognize that even if one were to adopt an evolutionary perspective on life\u2019s origin, it looks as if a Mind is responsible for jimmy-rigging the process to a predetermined endpoint. It looks as if a Mind purposed for life to be present in the universe and structured the laws of nature so that, in this case, the uniquely optimal canonical set of amino acids would inevitably emerge.<\/p>\n<p>Along these lines, it is remarkable to think that the canonical set of amino acids has the precise properties needed for life to exist. This \u201ccoincidence\u201d is eerie, to say the least. As a biochemist, I interpret this coincidence as evidence that our universe has been designed for a purpose. It is provocative to think that regardless of one\u2019s perspective on the origin of life, the evidence converges toward a single conclusion: namely that life manifests from an intelligent agent\u2014God.<\/p>\n<p><strong>Resources<\/strong><\/p>\n<ul>\n<li><em><a href=\"https:\/\/support.reasons.org\/purchase\/the-cells-design\">The Cell\u2019s Design: How Chemistry Reveals the Creator\u2019s Artistry<\/a> <\/em>by Fazale Rana (book)<\/li>\n<\/ul>\n<p><u>The Optimality of Biochemical Systems<\/u><\/p>\n<ul>\n<li>\u201c<a href=\"http:\/\/www.reasons.org\/todays-new-reason-to-believe\/read\/tnrtb\/2007\/07\/02\/the-genetic-code-simply-the-best\">The Genetic Code: Simply the Best<\/a>\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"https:\/\/www.reasons.org\/the-cells-design\/read\/the-cells-design\/2018\/10\/03\/the-optimal-design-of-the-genetic-code\">The Optimal Design of the Genetic Code<\/a>\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"\/todays-new-reason-to-believe\/read\/tnrtb\/2008\/08\/21\/biochemical-synonyms-optimized-part-1-of-2\">Biochemical Synonyms Optimized, Part 1<\/a>\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"\/todays-new-reason-to-believe\/read\/tnrtb\/2008\/08\/28\/biochemical-synonyms-optimized-part-2-of-2\">Biochemical Synonyms Optimized, Part 2<\/a>\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"http:\/\/www.reasons.org\/the-cells-design\/read\/the-cells-design\/2018\/02\/21\/protein-amino-acids-form-a-just-right-set-of-biological-building-blocks\">Protein Amino Acids Form a \u201cJust-Right\u201d Set of Building Blocks<\/a>\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"\/todays-new-reason-to-believe\/read\/tnrtb\/2012\/03\/12\/why-these-20-amino-acids\">Why These 20 Amino Acids<\/a>\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"\/todays-new-reason-to-believe\/read\/tnrtb\/2012\/07\/09\/the-optimal-design-of-metabolism\">Optimal Design of Metabolism<\/a>\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"\/explore\/publications\/nrtb-e-zine\/read\/nrtb-e-zine\/2009\/01\/01\/metabolism-a-cascade-of-design\">Metabolism: A Cascade of Design<\/a>\u201d by Fazale Rana (article)<\/li>\n<\/ul>\n<p><u>The Biochemical Anthropic Principle<\/u><\/p>\n<ul>\n<li>\u201c<a href=\"https:\/\/www.reasons.org\/todays-new-reason-to-believe\/read\/tnrtb\/2015\/02\/10\/how-the-central-dogma-of-molecular-biology-points-to-design\">How the Central Dogma of Molecular Biology Points to Design<\/a>\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"https:\/\/www.reasons.org\/the-cells-design\/read\/the-cells-design\/2016\/11\/09\/the-logic-of-dna-replication-makes-a-case-for-intelligent-design\">The Logic of DNA Replication Makes a Case for Intelligent Design<\/a>\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"http:\/\/www.reasons.org\/the-cells-design\/read\/the-cells-design\/2018\/02\/21\/protein-amino-acids-form-a-just-right-set-of-biological-building-blocks\">Protein Amino Acids Form a \u201cJust-Right\u201d Set of Building Blocks<\/a>\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"\/todays-new-reason-to-believe\/read\/tnrtb\/2012\/03\/12\/why-these-20-amino-acids\">Why These 20 Amino Acids<\/a>\u201d<span> <\/span>by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"https:\/\/www.reasons.org\/todays-new-reason-to-believe\/read\/tnrtb\/2016\/02\/11\/a-periodic-table-for-protein-structures-reveals-biochemical-design\">A Periodic Table for Protein Structures Reveals Biochemical Design<\/a>\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"https:\/\/www.reasons.org\/the-cells-design\/read\/the-cells-design\/2019\/05\/29\/biochemical-grammar-communicates-the-case-for-creation\">Biochemical Grammar Communicates the Case for Creation<\/a>\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"https:\/\/www.reasons.org\/the-cells-design\/read\/the-cells-design\/2019\/02\/27\/molecular-logic-of-the-electron-transport-chain-supports-creation\">Molecular Logic of the Electron Transport Chain Supports Creation<\/a>,\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"https:\/\/www.reasons.org\/the-cells-design\/read\/the-cells-design\/2017\/11\/22\/fatty-acids-are-beautiful\">Fatty Acids Are Beautiful<\/a>\u201d by Fazale Rana (article)<\/li>\n<\/ul>\n<div class=\"footnotes\">\n<h5>Endnotes<\/h5>\n<ol>\n<li>Melissa Ilardo et al., \u201cAdaptive Properties of the Genetically Encoded Amino Acid Alphabet Are Inherited from Its Subset,\u201d <em>Scientific Reports <\/em>9, no. 12468 (August 28, 2019), doi:<a href=\"https:\/\/www.nature.com\/articles\/s41598-019-47574-x\">10.1038\/s41598-019-47574-x<\/a>.<\/li>\n<li><span>Arthur L. Weber and Stanley L. Miller, <\/span><span><\/span><span>\u201cReasons for the Occurrence of the Twenty Coded Protein Amino Acids,\u201d<\/span><span> <\/span><span><em>Journal of Molecular Evolution<\/em><\/span><span> <\/span><span>17, no. 5 (September 1981): 273\u201384, doi:<a href=\"https:\/\/www.springerlink.com\/content\/t746466251668633\/\">10.1007\/BF01795749<\/a>; H. James Cleaves II,<\/span><span> <\/span><span>\u201cThe Origin of the Biologically Coded Amino Acids,\u201d<\/span><span> <\/span><span><em>Journal of Theoretical Biology<\/em><\/span><span> <\/span><span>263, no. 4 (April 2010): 490\u201398, doi:<a class=\"doi\" href=\"https:\/\/doi.org\/10.1016\/j.jtbi.2009.12.014\" target=\"_blank\" rel=\"noopener noreferrer\" aria-label=\"Persistent link using digital object identifier\" title=\"Persistent link using digital object identifier\">10.1016\/j.jtbi.2009.12.014<\/a>.<\/span><\/li>\n<li><span>Gayle K. Philip and Stephen J. Freeland, <\/span><span><\/span><span>\u201cDid Evolution Select a Nonrandom \u2018Alphabet\u2019 of Amino Acids?\u201d<\/span><span> <em>Astrobiology<\/em> 11, no. 3 (April 2011), 235\u201340, doi:<a href=\"https:\/\/doi.org\/10.1089\/ast.2010.0567\" class=\"epub-section__doi__text\">10.1089\/ast.2010.0567<\/a>; Matthias Granhold et al., \u201cModern Diversification of the Amino Acid Repertoire Driven by Oxygen,\u201d <em>Proceedings of the National Academy of Sciences, USA <\/em>115, no. 1 (January 2, 2018): 41\u201346, doi:<a href=\"https:\/\/doi.org\/10.1073\/pnas.1717100115\">10.1073\/pnas.1717100115<\/a>.<\/span><\/li>\n<li>Ilardo et al., \u201cAdaptive Properties.\u201d<\/li>\n<li>J. Tze-Fei Wong and Patricia M. Bronskill, \u201cInadequacy of Prebiotic Synthesis as Origin of Proteinous Amino Acids,\u201d <em>Journal of Molecular Evolution <\/em>13, no. 2 (June 1979): 115\u201325, doi:<a href=\"https:\/\/link.springer.com\/article\/10.1007\/BF01732867\">10.1007\/BF01732867<\/a>.<\/li>\n<li>Tokyo Institute of Technology, \u201cScientists Find Biology\u2019s Optimal \u2018Molecular Alphabet\u2019 May Be Preordained,\u201d <em>ScienceDaily, <\/em>September 10, 2019, <a href=\"http:\/\/www.sciencedaily.com\/releases\/2019\/09\/190910080017.htm\">http:\/\/www.sciencedaily.com\/releases\/2019\/09\/190910080017.htm<\/a>.<\/li>\n<li>Tokyo Institute, \u201cScientists Find.\u201d<\/li>\n<\/ol>\n<\/div>\n<p><!-- CONTENT ENDS -->\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Explore how the universal set of 20 protein amino acids reveals biochemical optimization pointing to intelligent design and a Creator.<\/p>\n","protected":false},"author":579,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_person_authors":[],"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","footnotes":"","_classifai_error":"","_classifai_text_to_speech_error":"","_classifai_text_to_speech_scheduled":false},"categories":[63990,63996],"tags":[70591,70588,70594],"discipline":[64076],"reading-level":[64149],"class_list":["post-10584","post","type-post","status-publish","format-standard","hentry","category-life","category-does-god-exist","tag-optimal-relationships","tag-genetic-design","tag-life-origins","discipline-biochemistry","reading-level-advanced-deep-dive"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.7 (Yoast SEO v28.0) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Is the Optimal Set of Protein Amino Acids Purposed by a Mind? 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