{"id":10941,"date":"2019-01-16T11:00:00","date_gmt":"2019-01-16T11:00:00","guid":{"rendered":"http:\/\/reasons.org\/prebiotic-chemistry-and-the-hand-of-god\/"},"modified":"2019-01-16T11:00:00","modified_gmt":"2019-01-16T11:00:00","slug":"prebiotic-chemistry-and-the-hand-of-god","status":"publish","type":"post","link":"https:\/\/reasons.org\/creation\/evolution\/prebiotic-chemistry-and-the-hand-of-god","title":{"rendered":"Prebiotic Chemistry and the Hand of God"},"content":{"rendered":"<section class=\"post-norm\">\n<div class=\"container\">\n<div class=\"row\">\n<div class=\"col-sm-8 col-sm-offset-2\">\n<!-- CONTENT BEGINS --><\/p>\n<blockquote>\n<p>\u201cMany of the experiments designed to explain one or other step in the origin of life are either of tenuous relevance to any believable prebiotic setting or involve an experimental rig in which the hand of the researcher becomes for all intents and purposes the hand of God.\u201d<\/p>\n<p style=\"text-align: right;\"><em>\u2014<a href=\"https:\/\/www.esc.cam.ac.uk\/directory\/simon-conway-morris\">Simon Conway Morris<\/a><\/em>, <a href=\"https:\/\/www.amazon.com\/Lifes-Solution-Inevitable-Humans-Universe-ebook\/dp\/B00E3UR48O\/ref=sr_1_1?ie=UTF8&amp;qid=1546888696&amp;sr=8-1&amp;keywords=Life%27s+Solution+simon+conway+morris\">Life\u2019s Solution<\/a><em> <\/em><\/p>\n<\/blockquote>\n<p>If you could time travel, would you? Would you travel to the past or the future?<\/p>\n<p>If asked this question, I bet many origin-of-life researchers would want to travel to the time in Earth\u2019s history when life originated. Given the many scientifically impenetrable mysteries surrounding life\u2019s genesis, I am certain many of the scientists working on these problems would love to see firsthand how life got its start.<\/p>\n<p>It is true, origin-of-life researchers have <em>some<\/em> access to the origin-of-life process through the fossil and geochemical records of the oldest rock formations on Earth\u2014yet this evidence only affords them a glimpse through the glass, dimly.<\/p>\n<p>Because of these limitations, origin-of-life researchers have to carry out most of their work in laboratory settings, where they try to replicate the myriad steps they think contributed to the origin-of-life process. Pioneered by the late <a href=\"https:\/\/en.wikipedia.org\/wiki\/Stanley_Miller\">Stanley Miller<\/a> in the early 1950s, this approach\u2014dubbed prebiotic chemistry\u2014has become a scientific subdiscipline in its own right.<\/p>\n<p><img decoding=\"async\" class=\"img-responsive center-block\" src=\"0ce67647-1f86-66f3-b463-ff00002b9606\" data-displaymode=\"Original\" alt=\"blog__inline-prebiotic-chemistry-and-the-hand-of-god-1\" title=\"blog__inline-prebiotic-chemistry-and-the-hand-of-god-1\" \/>\n<\/p>\n<p style=\"text-align: left;\"><em><strong>Figure 1: Chemist Stanley Miller, circa 1980. <\/strong>Image credit: <a href=\"https:\/\/en.wikipedia.org\/wiki\/Stanley_Miller#\/media\/File:Miller1999.jpg\">Wikipedia<\/a><\/em><\/p>\n<p><strong>Prebiotic Chemistry<\/strong><\/p>\n<p>In effect, the goals of prebiotic chemistry are threefold.<\/p>\n<ul>\n<li><em>Proof of principle. <\/em>The objective of these types of experiments is to determine\u2014in principle\u2014if a chemical or physical process that could potentially contribute to one or more steps in the origin-of-life pathway even exists.<\/li>\n<li><em>Mechanism studies. <\/em>Once processes have been identified that could contribute to the emergence of life, researchers study them in detail to get at the mechanisms undergirding these physicochemical transformations.<\/li>\n<li><em>Geochemical relevance. <\/em>Perhaps the most important goal of prebiotic studies is to establish the geochemical relevance of the physicochemical processes believed to have played a role in life\u2019s start. In other words, how well do the chemical and physical processes identified and studied in the laboratory translate to early Earth\u2019s conditions?<\/li>\n<\/ul>\n<p>Without question, over the last 6 to 7 decades, origin-of-life researchers have been wildly successful with respect to the first two objectives. It is safe to say that origin-of-life investigators have demonstrated that\u2014<em>in principle<\/em>\u2014the chemical and physical processes needed to generate life through chemical evolutionary pathways exist.<\/p>\n<p>But when it comes to the third objective, origin-of-life researchers have experienced frustration\u2014and, arguably, failure.<\/p>\n<p><strong>Researcher Intervention and Prebiotic Chemistry<\/strong><\/p>\n<p>In an ideal world, humans would not intervene at all in any prebiotic study. But this ideal isn\u2019t possible. Researchers involve themselves in the experimental design out of necessity, but also to ensure that the results of the study are reproducible and interpretable. If researchers don\u2019t set up the experimental apparatus, adjust the starting conditions, add the appropriate reactants, and analyze the product, then by definition the experiment would never happen. Utilizing carefully controlled conditions and chemically pure reagents is necessary for reproducibility and to make sense of the results. In fact, this level of control is essential for proof-of-principle and mechanistic prebiotic studies\u2014and perfectly acceptable.<\/p>\n<p>However, when it comes to prebiotic chemistry\u2019s third goal, geochemical relevance, the highly controlled conditions of the laboratory become a liability. Here researcher intervention becomes potentially unwarranted. It goes without saying that the conditions of early Earth were uncontrolled and chemically and physically complex. Chemically pristine and physically controlled conditions didn\u2019t exist. And, of course, origin-of-life researchers weren\u2019t present to oversee the processes and guide them to their desired end. Yet, it is rare for prebiotic simulation studies to fully take the actual conditions of early Earth into account in the experimental design. It is rarer for origin-of-life investigators to acknowledge this limitation.<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"img-responsive center-block\" src=\"1ce67647-1f86-66f3-b463-ff00002b9606\" data-displaymode=\"Original\" alt=\"blog__inline-prebiotic-chemistry-and-the-hand-of-god-2\" title=\"blog__inline-prebiotic-chemistry-and-the-hand-of-god-2\" \/><\/p>\n<p style=\"text-align: left;\"><em><strong>Figure 2: Laboratory technician. <\/strong>Image credit: Shutterstock<\/em><\/p>\n<p>This complication means that many prebiotic studies designed to simulate processes on early Earth seldom accomplish anything of the sort due to excessive researcher intervention. Yet, it isn\u2019t always clear when examining an experimental design if researcher involvement is legitimate or unwarranted.<\/p>\n<p>As I point out in my book <a href=\"https:\/\/support.reasons.org\/purchase\/creating-life-in-the-lab\"><em>Creating Life in the Lab<\/em><\/a> (Baker, 2011), one main reason for the lack of progress relates to the researcher\u2019s role in the experimental design\u2014a role not often recognized when experimental results are reported. Origin-of-life investigator Clemens Richert from the University of Stuttgart in Germany now acknowledges this very concern in a recent comment piece published by <em>Nature Communications<\/em>.<sup>1  <\/sup><\/p>\n<p>As Richert points out, the role of researcher intervention and a clear assessment of geochemical relevance is rarely acknowledged or properly explored in prebiotic simulation studies. To remedy this problem, Richert calls for origin-of-life investigators to do three things when they report the results of prebiotic studies.<\/p>\n<ul>\n<li>State explicitly the number of instances in which researchers engaged in manual intervention.<\/li>\n<li>Describe precisely the prebiotic scenario a particular prebiotic simulation study seeks to model.<\/li>\n<li>Reduce the number of steps involving manual intervention in whatever way possible.<\/li>\n<\/ul>\n<p>Still, as Richert points out, it is not possible to provide a quantitative measure (a score) of geochemical relevance. And, hence, there will always be legitimate disagreement about the geochemical relevance of any prebiotic experiment.<\/p>\n<p>Yet, Richert\u2019s commentary represents an important first step toward encouraging more realistic prebiotic simulation studies and a more cautious approach to interpreting the results of these studies. Hopefully, it will also lead to a more circumspect assessment on the importance of these types of studies for accounting for the various steps in the origin-of-life process.<\/p>\n<p><span style=\"color: #ff00ff;\"><\/span><strong>Researcher Intervention and the Hand of God<\/strong><\/p>\n<p>One concern not addressed by Richert in his commentary piece is the fastidiousness of many of the physicochemical transformations origin-of-life researchers deem central to chemical evolution. As I discuss in <a href=\"https:\/\/support.reasons.org\/purchase\/creating-life-in-the-lab\">Creating Life in the Lab<\/a>, mechanistic studies indicate that these processes are often dependent upon exacting conditions in the laboratory. To put it another way, these processes only take place\u2014even under the most ideal laboratory conditions\u2014because of human intervention. As a corollary, these processes would be unproductive on early Earth. They often require chemically pristine conditions, unrealistically high concentrations of reactants, carefully controlled order of additions, carefully regulated temperature, pH, salinity levels, etc.<\/p>\n<p>As Richert states, \u201cIt\u2019s not easy to see what replaced the flasks, pipettes, and stir bars of a chemistry lab during prebiotic evolution, let alone the hands of the chemist who performed the manipulations. (And yes, most of us are not comfortable with the idea of divine intervention.)\u201d<sup>2<\/sup><\/p>\n<p><span style=\"color: #ff00ff;\"><span style=\"color: #000000;\">Sadly, since I made the point about researcher intervention nearly a decade ago, it has often been ignored, dismissed, and even ridiculed by many in the scientific community\u2014simply because I have the temerity to think that a Creator brought life into existence.<\/span><\/span><\/p>\n<p>Even though Richert and his many colleagues in the origin-of-life research community do whatever they can to eschew a Creator\u2019s role in the origin-of-life, could it be that abiogenesis (life from nonlife) required the hand of God\u2014divine intervention?<\/p>\n<p>I would argue that this conclusion follows from nearly seven decades of work in prebiotic chemistry and the consistent demonstration of the central role that origin-of-life researchers play in the success of prebiotic simulation studies. It is becoming increasingly evident for whoever will \u201csee\u201d that the hand of the researcher serves as the analog for the hand of God.<\/p>\n<p><strong>Resources<\/strong><\/p>\n<ul>\n<li>\u201c<a href=\"https:\/\/www.reasons.org\/todays-new-reason-to-believe\/read\/tnrtb\/2007\/08\/09\/ask-not-for-whom-the-bell-tolls\">Ask Not for Whom the Bell Tolls<\/a>\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"https:\/\/www.reasons.org\/todays-new-reason-to-believe\/read\/tnrtb\/2007\/08\/01\/biology-textbooks-get-it-wrong-on-lifes-origin\">Biology Textbooks Get It Wrong on Life\u2019s Origin<\/a>\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"https:\/\/www.reasons.org\/todays-new-reason-to-believe\/read\/tnrtb\/2009\/08\/12\/rescuing-the-rna-world-part-1-of-2\">Rescuing the RNA World?, Part 1<\/a>\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"https:\/\/www.reasons.org\/todays-new-reason-to-believe\/read\/tnrtb\/2009\/08\/19\/rescuing-the-rna-world-part-2-of-2\">Rescuing the RNA World?, Part 2<\/a>\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"https:\/\/www.reasons.org\/the-cells-design\/read\/the-cells-design\/2016\/08\/31\/have-origin-of-life-researchers-found-the-rna-world-money-train\">Have Origin-of-Life Researchers Found the RNA World \u2018Money Train\u2019?<\/a>\u201d by Fazale Rana (article)<\/li>\n<li>\u201c<a href=\"https:\/\/www.reasons.org\/explore\/publications\/tnrtb\/read\/tnrtb\/2014\/06\/12\/hypernaturalism-and-the-origin-of-life\">Hypernaturalism and the Origin of Life<\/a>\u201d by Fazale Rana, Hugh Henry and Daniel J. Dyke (article)<\/li>\n<li><a href=\"https:\/\/support.reasons.org\/purchase\/creating-life-in-the-lab\"><em>Creating Life in the Lab: How Advances in Synthetic Biology Make a Case for a Creator<\/em><\/a> by Fazale Rana (book)<\/li>\n<\/ul>\n<div class=\"footnotes\">\n<h5>Endnotes<\/h5>\n<ol>\n<li>Clemens Richert, \u201c<a href=\"https:\/\/www.nature.com\/articles\/s41467-018-07219-5\">Prebiotic Chemistry and Human Intervention<\/a>,\u201d <em>Nature Communications <\/em>9 (December 12, 2018): 5177, <a href=\"https:\/\/www.nature.com\/articles\/s41467-018-07219-5\">doi:10.1038\/s41467-018-07219-5<\/a>.<\/li>\n<li>Richert, \u201c<a href=\"https:\/\/www.nature.com\/articles\/s41467-018-07219-5\">Prebiotic Chemistry.<\/a>\u201d<\/li>\n<\/ol>\n<\/div>\n<p><!-- CONTENT ENDS -->\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Explore the challenges of prebiotic chemistry and the role of researcher intervention in origin-of-life studies, questioning naturalistic explanations.<\/p>\n","protected":false},"author":579,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_person_authors":[],"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","footnotes":"","_classifai_error":"","_classifai_text_to_speech_error":"","_classifai_text_to_speech_scheduled":false},"categories":[63996,63987],"tags":[70784,70594,71098],"discipline":[64076],"reading-level":[64149],"class_list":["post-10941","post","type-post","status-publish","format-standard","hentry","category-does-god-exist","category-evolution","tag-abiogenesis","tag-life-origins","tag-prebiotic-chemistry","discipline-biochemistry","reading-level-advanced-deep-dive"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.7 (Yoast SEO v28.0) - 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